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Selected Publications

Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31. Full Text

Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Rios Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nat Commun, 2015 Sep 10. doi: 10.1038/ncomms9164. Full Text

Schachtrup C, Ryu JK, Mammadzada K, Khan AS, Carlton PM, Perez A, Christian F, Le Moan N, Vagena E, Baeza-Raja B, Rafalski V, Chan JP, Nitschke R, Houslay MD, Ellisman MH, Wyss-Coray T, Palop JJ, Akassoglou K. Nuclear pore complex remodeling by p75NTR cleavage controls TGF-β signaling and astrocyte functions. Nat Neurosci, 2015. doi: 10.1038/nn.4054. Full Text

Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Ann Neurol, 2014. 75:303-8. Full Text

Davalos D, Ryu JK, Merlini M, Baeten KM, Le Moan N, Petersen MA, Deerinck TJ, Smirnoff DS, Bedard C, Hakozaki H, Gonias Murray S, Ling JB, Lassmann H, Degen JL, Ellisman MH, Akassoglou K. Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nature Commun, 2012. 3:1227. Full Text | Movie 1 | Movie 2 | Movie 3 | Movie 4 | Movie 5 | Movie 6 | Movie 7

Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. PNAS, 2012. 109:5838-43. Full Text

Le Moan N, Houslay DM, Christian F, Houslay MD, Akassoglou K. Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1 alpha. Mol Cell, 2011. 44:476-90. Full Text

Baeten KM, Akassoglou K. Extracellular matrix and matrix receptors in blood-brain-barrier formation and stroke. Dev Neurobiology, 2011. 71:1018-39. Full Text

Schachtrup C, Le Moan N, Passino M, Akassoglou K. Hepatic stellate cells and astrocytes: Stars of scar formation and tissue repair. Cell Cycle, 2011. 10:1764-71. Full Text

Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte acar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci, 2010. 30:5843-54. PDF | Supplemental

Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature, 2008. 453:807-11. PDF | Supplemental | Editor’s Choice Science STKE

Davalos D, Lee JK, Brinkman B, Zheng B, Akassoglou K. Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J Neurosci Methods, 2008. 169:1-7. Full Text | Movie 1 | Movie 2 | Movie 3 | Movie 4

Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: Lessons from multiple sclerosis. Curr Med Chem, 2007. 14:2925-36. Abstract

Adams Schachtrup C, Lu P, Lee JK, Jones L, Sachs BD, Ju J, Zheng B, Akassoglou K. Fibrinogen inhibits neurite outgrowth via β3 integrin-mediated transactivation of the EGF receptor. Proc Natl Acad Scie USA, 2007. 104:11814-19. Full Text | Supplemental | News

Sachs B.D., Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, Chao MV, Akassoglou K. p75 Neurotrophin Receptor Regulates Tissue Fibrosis through Inhibition of Plasminogen Activation via a PDE4/cAMP/PKA Pathway. J Cell Biol, 2007. 177:1119-32. Full Text | Supplemental | Editor’s Choice Science STKE | JCB In this Issue: Scarred by a Death Receptor | News

Passino MA, Adams, RA, Sikorski SL, Akassoglou K. Regulation of hepatic stellate cell differentiation by the neurotrophin receptor p75NTR. Science, 2007. 315:1853-56 Full Text | Supplemental | Editor’s Choice Science STKE | This Week in Science | News

Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and reverses relapsing paralysis in central nervous system autoimmune disease. J Exp Med, 2007. 204, 571-82. Full Text
JEM In this issue: Saving myelin from microglia | News

Adams RA, Passino M, Sachs B, Nuriel T, Akassoglou K. Fibrin mechanisms and functions in nervous system pathology. Mol Interven, 2004. 4:163-76. Full Text

Akassoglou K, Adams RA, Bauer J, Mercado P, Tseveleki V, Lassmann H, Probert L, Strickland S. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc Natl Acad Sci USA, 2004. 101:6698-703. Full Text | News

Akassoglou K, Yu W-M, Akpinar P, Strickland S. Fibrin inhibits peripheral nerve regeneration by arresting Schwann cell differentiation. Neuron, 2002. 33: 861-75. Full Text | Editor’s Choice Science STKE | News

Akassoglou K, Strickland S. Nervous system pathologies: The fibrin perspective. Biol Chem, 2002. 383:37-45. Abstract

Probert L, Akassoglou K. Glial expression of cytokines in transgenic animals- how do these models reflect the “normal situation”. Glia, 2001. 36:212-19. Abstract

Akassoglou K, Kombrink KW, Degen JL, Strickland S. Tissue plasminogen activator-mediated fibrinolysis protects from axonal demyelination after sciatic nerve injury. J Cell Biol, 2000. 149:1157-66. Full Text

Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G and Probert L. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the CNS of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol, 1998. 153:801-13. Full Text

Akassoglou K, Probert L, Kontogeorgos G and Kollias G. Astrocyte, but not neuron-specific, transmembrane TNF triggers inflammation and degeneration in the CNS of transgenic mice. J Immunol, 1997. 158:438-45. Abstract